Detailed view for TcCLB.503971.30

Basic information

TDR Targets ID: 46647
Trypanosoma cruzi, Got1/Sft2-like family, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.0016 | Length (AA): 172 | MW (Da): 19054 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04178   Got1/Sft2-like family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016192   vesicle-mediated transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
55 97 4a01 (A) 17 89 37.00 0.47 0 0.2249 2.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128482)

Species Accession Gene Product
Arabidopsis thaliana AT5G23550   Got1/Sft2-like vescicle transport protein
Arabidopsis thaliana AT5G24170   Got1/Sft2-like vescicle transport protein family
Caenorhabditis elegans CELE_F27D4.7   Protein F27D4.7
Dictyostelium discoideum DDB_G0291055   hypothetical protein
Drosophila melanogaster Dmel_CG5104   CG5104 gene product from transcript CG5104-RB
Echinococcus granulosus EgrG_000167600   Vesicle transport protein SFT2B
Entamoeba histolytica EHI_000640   hypothetical protein, conserved
Entamoeba histolytica EHI_200980   hypothetical protein, conserved
Entamoeba histolytica EHI_188010   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000167600   Vesicle transport protein SFT2B
Homo sapiens 375035   SFT2 domain containing 2
Homo sapiens 113402   SFT2 domain containing 1
Leishmania braziliensis LbrM.03.0830   hypothetical protein, conserved
Leishmania donovani LdBPK_050810.1   Got1/Sft2-like family, putative
Leishmania donovani LdBPK_030900.1   Got1/Sft2-like family, putative
Leishmania infantum LinJ.03.0900   hypothetical protein, conserved
Leishmania infantum LinJ.05.0810   hypothetical protein, conserved
Leishmania major LmjF.05.0810   hypothetical protein, conserved
Leishmania major LmjF.03.0920   hypothetical protein, conserved
Leishmania mexicana LmxM.03.0920   hypothetical protein, conserved
Leishmania mexicana LmxM.05.0810   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00785   hypothetical protein
Mus musculus ENSMUSG00000040848   SFT2 domain containing 2
Mus musculus ENSMUSG00000073468   SFT2 domain containing 1
Neospora caninum NCLIV_021350   SFT2 domain containing 1, related
Oryza sativa 4329697   Os02g0564500
Onchocerca volvulus OVOC317  
Schistosoma japonicum Sjp_0092870   Vesicle transport protein SFT2B, putative
Schistosoma mansoni Smp_002100   hypothetical protein
Schmidtea mediterranea mk4.009401.00  
Schmidtea mediterranea mk4.004674.01  
Schmidtea mediterranea mk4.002743.03  
Trypanosoma brucei gambiense Tbg972.11.12310   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.7.8310   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.7060   Got1/Sft2-like family, putative
Trypanosoma brucei Tb927.11.10980   Got1/Sft2-like family, putative
Trypanosoma congolense TcIL3000.11.11700   Got1/Sft2-like family, putative
Trypanosoma congolense TcIL3000_7_5740   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508181.149   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503971.30   Got1/Sft2-like family, putative
Trypanosoma cruzi TcCLB.508269.20   Got1/Sft2-like family, putative
Trypanosoma cruzi TcCLB.510617.10   Got1/Sft2-like family, putative
Trypanosoma cruzi TcCLB.506789.300   Got1/Sft2-like family, putative
Toxoplasma gondii TGME49_203700   SFT2 family protein
Trichomonas vaginalis TVAG_390730   Vesicle transport protein SFT2A, putative

Essentiality

TcCLB.503971.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.2770 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.2770 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.2770 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.2770 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.7.7060 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.7060 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.7060 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.7060 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_203700 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.503971.30 (Trypanosoma cruzi), Got1/Sft2-like family, putative
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